Director, Medical Affairs Operations

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response.  We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.  

Reporting to the Head of Medical Affairs, the Director, Medical Affairs Operations is the operational backbone of Lyell’s growing Medical Affairs function. As the team scales toward potential launch, this role builds and runs the systems, processes, and execution engine that allow Medical Affairs to operate with speed, consistency, and compliance — spanning scientific congresses and advisory boards, the Materials Review Committee (MRC), field medical support, budget and vendor management, and performance metrics.

This is a role for a rare orchestrator-operator: someone who can design the operating model and also personally execute — building the trackers, dashboards, and AI-enabled workflows themselves rather than only sponsoring them. The Director is expected to be an AI vanguard within Medical