Product Manager, AI Platform & Partnerships

🏢 Manifoldbio · 📍 Boston or San Francisco 💰 $165,000 - $165,000 / yr

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Position Summary & Responsibilities

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

Manifold Bio is seeking a Product Manager to serve as the internal product owner for our AI projects, leading the roadmap across key domains including protein design, foundation models, reasoning models, agents, and infrastructure. This role covers both internal product management and liaising with AI / tech partners., Internal responsibilities include interfacing with the AI team and R&D project managers to translate ambitious AI x biology ideas into shipped internal products and platform capabilities. External responsibilities include developing and nurturing relationships with external AI teams and partners, with an opportunity to flex into business development and strategic transactions. This role works closely with our co-founders, AI/ML leadership, and BD team to turn cutting-edge capabilities into durable platform assets.

Responsibilities

Define the product vision, roadmap, and success metrics for Manifold’s AI platform capabilities, including protein design, foundation models, and agents
Translate internal R&D and AI x biology ideas into concrete requirements and run the operating cadences that drive decisions and

🎯 Candidate Preparation Guide For Manifoldbio Applicants

Key Role Competencies & Evaluation Highlights

Key Role Focus:

Scientific rigor combined with high-velocity engineering is tested intensely; interviewers look for pioneers who can build multiplexed protein measurement platforms at scale.

📋 Preparation Priorities (Key Areas to Clarify):

1. Working strictly in academic silos without an appreciation for commercial drug discovery timelines
2. Inability to troubleshoot unexpected assay failures with data-driven pragmatism
3. Resistance to cross-disciplinary collaboration between wet-lab scientists and computational teams

✨ Recommended Role Alignment Hook:

I build high-throughput protein measurement engines that accelerate therapeutic discovery by turning complex biological data into actionable insights.

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